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The most commonly reported side effects were: History of serious hypersensitivity reaction (e.g., Stevens-Johnson syndrome, anaphylactic reaction, angioedema) to carvedilol or any of the components of COREG CR.Patients in cardiogenic shock or decompensated heart failure requiring the use of IV inotropic therapy.Severe bradycardia (unless permanent pacemaker in place).Bronchial asthma or related bronchospastic conditions.Certain other medications may affect how COREG CR works.ĭo not take COREG CR if you have any of the following: Tell your doctor about all the medications you take. Subsequent titration to higher doses should, as appropriate, be made after an interval of at least 2 weeks.ĭo not abruptly stop taking COREG CR, as it may lead to acute exacerbation of coronary artery disease upon cessation of therapy.īradycardia, hypotension, worsening heart failure/fluid retention may occur. ( 2.5)Ĭapsules: 10, 20, 40, 80 mg ( 3) Dosing Conversion from Immediate-Release Daily Dose of Immediate-Release Carvedilol TabletsĪ When switching from carvedilol 12.5 mg or 25 mg twice daily, a starting dose of COREG CR 20 mg or 40 mg once daily, respectively, may be warranted for elderly patients or those at increased risk of hypotension, dizziness, or syncope. Elderly patients (>65 years of age): When switching from higher doses of immediate-release carvedilol to COREG CR®, a lower starting dose should be considered to reduce the risk of hypotension and syncope.Hypertension: Start at 20 mg once daily and increase if needed for blood pressure control to 40 mg then 80 mg once daily over intervals of 1 to 2 weeks.A lower starting dose or slower titration may be used. Left ventricular dysfunction following myocardial infarction: Start at 20 mg once daily and increase to 40 mg then 80 mg once daily after intervals of 3 to 10 days.Maintain lower doses if higher doses are not tolerated. Heart failure: Start at 10 mg once daily and increase to 20, 40, and then 80 mg once daily over intervals of at least 2 weeks.Individualize dosage and monitor during up-titration.